Invention Grant
- Patent Title: Pharmaceutical targeting of a mammalian cyclic di-nucleotide signaling pathway
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Application No.: US14653586Application Date: 2013-12-16
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Publication No.: US10336786B2Publication Date: 2019-07-02
- Inventor: Zhijian Chen , Lijun Sun , Jiaxi Wu , Heping Shi , Chuo Chen
- Applicant: Board of Regents, The University of Texas System
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Dechert LLP
- Agent Carl A. Morales; Seth E. Snyder
- International Application: PCT/US2013/075509 WO 20131216
- International Announcement: WO2014/099824 WO 20140626
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A61K39/39 ; C12Q1/6876 ; C12Q1/25 ; G01N33/573 ; A61K31/7084 ; G01N33/564 ; A61K39/00
Abstract:
Cyclic-GMP-AMP synthase (cGAS) and cyclic-GMP-AMP (cGAMP), including 2′3-cGAMP, 2′2-cGAMP, 3′2′-cGAMP and 3′3′-GAMP, are used in pharmaceutical formulations (including vaccine adjuvants), drug screens, therapies and diagnostics.
Public/Granted literature
- US20150343056A1 PHARMACEUTICAL TARGETING OF A MAMMALIAN CYCLIC DI-NUCLEOTIDE SIGNALING PATHWAY Public/Granted day:2015-12-03
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