Invention Grant
- Patent Title: Fc variants with altered binding to FcRn
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Application No.: US14459160Application Date: 2014-08-13
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Publication No.: US10336818B2Publication Date: 2019-07-02
- Inventor: Aaron Keith Chamberlain , Bassil Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- Applicant: Xencor, Inc.
- Applicant Address: US CA Monrovia
- Assignee: Xencor, Inc.
- Current Assignee: Xencor, Inc.
- Current Assignee Address: US CA Monrovia
- Agency: Morgan, Lewis & Bockius, LLP
- Agent Gargi Talukder; Robin M. Silva
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N5/00 ; C12N1/20 ; C12P21/06 ; C12P21/04 ; C07K16/18 ; C07K16/08 ; C07K16/22 ; C07K16/24 ; C07K16/28 ; C07K16/32 ; C07K16/42 ; C07K14/715 ; C07K16/00 ; A61K39/00
Abstract:
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
Public/Granted literature
- US20150191533A1 Fc VARIANTS WITH ALTERED BINDING TO FcRn Public/Granted day:2015-07-09
Information query
