Invention Grant
- Patent Title: Methods and compositions for treating a subject with a SMAD7 antisense oligonucleotide
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Application No.: US15519468Application Date: 2015-10-16
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Publication No.: US10337004B2Publication Date: 2019-07-02
- Inventor: Giovanni Monteleone
- Applicant: Nogra Pharma Limited
- Applicant Address: IE Dublin
- Assignee: Nogra Pharma Limited
- Current Assignee: Nogra Pharma Limited
- Current Assignee Address: IE Dublin
- Agency: Goodwin Procter LLP
- International Application: PCT/EP2015/074066 WO 20151016
- International Announcement: WO2016/059239 WO 20160421
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; C12Q1/6883
Abstract:
The present invention relates to treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis) using antisense nucleotides that are directed against polymorphic forms (e.g., those containing single nucleotide polymorphisms) of the SMAD7 mRNA. The invention thus relates to treatment methods for subjects having polymorphic forms of SMAD7 and antisense oligonucleotides that specifically target SMAD7 mRNA transcripts containing polymorphisms.
Public/Granted literature
- US20170240893A1 METHODS AND COMPOSITIONS FOR TREATING A SUBJECT WITH A SMAD7 ANTISENSE OLIGONUCLEOTIDE Public/Granted day:2017-08-24
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