Systems and methods can support a sensor mesh and signal transmission architecture for electromagnetic signature analysis and threat detection. Sensor antennas may be deployed within an electromagnetic environment. A configurable antenna feed network can couple radio frequency signals from the antennas to both software-defined radio receivers and hardware-defined radio receivers. A raw signal analysis engine associated with the software-defined radio receiver can receive digital samples of the radio frequency signals, identify signal features within the digital samples, and generate signal feature vectors from the identified signal features. A signal feature network can receive the signal feature. A signal aggregation and analysis engine can receive the signal feature vectors from the signal feature network, aggregate the signal feature vectors, process the signal feature vectors, and identify wireless attacks according to the signal features within the signal feature vectors. One or more updatable analysis databases can support the signal processing operations.