Provided are a pixel driving structure, in which the nth column of TFTs (T) are arranged at positions where the nth column of sub pixels (P) is close to the nth data line (D(n)); in the nth column of sub pixels (P), four sub pixels (P) or two sub pixels (P), which are adjacent vertically in the upper and the lower are set to be a pixel group (PG), and the nth data line (D(n)) sets a signal period to define polarities of respective sub pixels (P) in the pixel group (PG) to make polarity inversion occur at a edge of the two adjacent pixel groups (PG) in the upper and the lower, and polarities of two adjacent columns of sub pixels (P) are opposite to achieve display effect similar to a dot inversion. The pixel aperture regions can be neatly aligned to prevent the color washout.