A remote access controller (RAC) service module performs a method of configuring an information handling system (IHS) to adaptively access a multipath storage area network (SAN). A RAC of the RAC service module receives an out-of-band communication containing a multipath solution from a management console. The RAC stores the multipath solution in persistent memory accessible to the RAC. The RAC, via a RAC service manager operating with an operating system of a host processor subsystem of the IHS, accesses system dependent multipath configuration (SDMC) file(s) in host system storage. The RAC creates system independent multipath configuration (SIMC) file(s) based on the multipath solution and the SDMC file(s). The RAC causes the RAC service manager to store the SIMC file(s) in system storage. The method includes triggering a system dependent multipath agent of the host operating system to configure multipath access to the SAN according to the SDMC and SIMC files.