Invention Grant
- Patent Title: Identification of multi-modal associations between biomedical markers
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Application No.: US13877346Application Date: 2011-10-04
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Publication No.: US10340027B2Publication Date: 2019-07-02
- Inventor: Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
- Applicant: Nilanjana Banerjee , Angel Janevski , Sitharthan Kamalakaran , Vinay Varadan , Nevenka Dimitrova , Robert Lucito
- Applicant Address: NL Eindhoven
- Assignee: Koninklijke Philips N.V.
- Current Assignee: Koninklijke Philips N.V.
- Current Assignee Address: NL Eindhoven
- International Application: PCT/IB2011/054366 WO 20111004
- International Announcement: WO2012/046191 WO 20120412
- Main IPC: G01N33/48
- IPC: G01N33/48 ; G16B25/00 ; G16B5/00 ; G06G7/58 ; G16B20/00

Abstract:
The present invention relates to a method for identifying multi-modal associations between biomedical markers which allows for the determination of network nodes and/or high ranking network members or combinations thereof, indicative of having a diagnostic, prognostic or predictive value for a medical condition, in particular ovarian cancer. The present invention further relates to a biomedical marker or group of biomedical markers associated with a high likelihood of responsiveness of a subject to a cancer therapy, preferably a platinum based cancer therapy, wherein said biomedical marker or group of biomedical markers comprises at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 8, 19, 20 or all markers selected from PKMYT1, SKIL, RAB8A, HIRIP3, CTNNB1, NGFR, ZCCHC11, LSP1, CD200, PAX8, CYBRD1, HOXC11, TCEAL1, FZD10, FZD1, BBS4, IRS2, TLX3, TSPAN2, TXN, and CFLAR. Furthermore, an assay for detecting, diagnosing, graduating, monitoring or prognosticating a medical condition, or for detecting, 1 diagnosing, monitoring or prognosticating the responsiveness of a subject to a therapy against said medical condition, in particular ovarian cancer, is provided, as well as a corresponding method for classifying a subject comprising and a medical decision support system.
Public/Granted literature
- US20130196877A1 IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS Public/Granted day:2013-08-01
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