A quantum interference device includes an atom cell module including an atom cell in which alkali metal is encapsulated, a light source that emits light adapted to excite the alkali metal, and a heater that heats the atom cell and the light source, a package that houses the atom cell module, and a controller adapted to control drive of the heater so that the light source becomes at a set temperature, R≤(Tv−Tout)/Qv is satisfied, where R [° C./W] is a thermal resistance between the atom cell module and the package, Tv [° C.] is the set temperature, Tout [° C.] is an upper limit value of a usage environmental temperature set to a value lower than the set temperature, Qv [W] is an amount of heat generation of the light source.