The present disclosure generally discloses an autonomous wireless transmission mechanism. The autonomous wireless transmission mechanism may be configured to support autonomous transmissions by wireless end devices to wireless access nodes in a connectionless manner. In general, an autonomous wireless transmission by a wireless end device may include transmission of a preamble in a preamble transmission zone and autonomous transmission of a payload over one or more resource units of one or more payload transmission zones without requiring establishment of a connection between the wireless end device and the wireless access node. The autonomous wireless transmission mechanism, by obviating the need for a wireless end device to establish a connection with a wireless access node in order to transmit data to the wireless access node, also obviates a need for the wireless end device to operate in a scheduled transmission mode.