A multimedia operation system includes a display, a display driver, a desk, a display control panel, an input/output interface driver, and an application processor. The display driver drives the display to display images. The display control panel is disposed in the desk, and outputs an initiation signal according to a user's operation. The input/output interface driver receives the initiation signal and outputs a menu activation signal according to the initiation signal. The application processor executes an application to generate multimedia data, controls the display driver to drive the display for displaying application images of the multimedia data, and controls the display driver to drive the display for displaying a menu image when receiving the menu activation signal.