A method and associated system are provided for producing a perforation line between adjacent lottery tickets in an automated production line wherein a substrate having lottery tickets printed thereon is conveyed through a perforation station in the production line prior to being folded into a Z-fold pattern for subsequent packaging. A perforation machine in the line is controlled by a controller for defining the perforation lines, wherein the control process includes determining the perforation lines that correspond to fold lines in the Z-fold pattern and, for these perforation lines, programming the perforation machine to generate a second perforation profile that is different from a first perforation profile of non-fold perforation lines that lie between the fold lines in the Z-fold pattern. The second perforation profile is specifically tailored to produce a stronger perforation line to compensate for weakness induced in the perforation line from being folded.