Invention Grant
- Patent Title: Cationic polymer coated mesoporous silica nanoparticles and uses thereof
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Application No.: US15698486Application Date: 2017-09-07
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Publication No.: US10343903B2Publication Date: 2019-07-09
- Inventor: Jeffrey I. Zink , Andre E. Nel , Tian Xia , Zhaoxia Ji , Huan Meng , Zongxi Li , Monty Liong , Min Xue , Derrick Y. Tarn , Sanaz Gardner
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Weaver Austin Villeneuve & Sampson LLP
- Agent Tom Hunter
- Main IPC: A61K9/14
- IPC: A61K9/14 ; B82Y5/00 ; A61K9/00 ; A61K9/51 ; A61K31/704 ; A61K31/713
Abstract:
A submicron structure having a silica body defining a plurality of pores is described. The submicron body may be spherical or non-spherical, and may include a cationic polymer or co-polymer on the surface of said silica body. The submicron structure may further include an oligonucleotide and be used to deliver the oligonucleotide to a cell. The submicron structure may further include a therapeutic agent and be used to deliver the therapeutic agent to a cell. An oligonucleotide and therapeutic agent may be used together. For example, when the oligonucleotide is an siRNA, the composition may be used to decrease cellular resistance to the therapeutic agent by decreasing translation of a resistance gene.
Public/Granted literature
- US20180155189A1 CATIONIC POLYMER COATED MESOPOROUS SILICA NANOPARTICLES AND USES THEREOF Public/Granted day:2018-06-07
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