Invention Grant
- Patent Title: Salt of quinolone compound, polymorphs thereof, preparation method therefor, composition, and applications
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Application No.: US16067144Application Date: 2016-12-29
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Publication No.: US10344035B2Publication Date: 2019-07-09
- Inventor: Jianxin Yu , Yu Hao , Jing Zhang , Fei Zhao , Leduo Zhang , Zhenying Liu , Gongsheng Li , Yuji Wang , Na Chen , Rui Bai , Yi Fan
- Applicant: SHANGHAI PHARMACEUTICALS HOLDING CO., LTD.
- Applicant Address: CN Shanghai
- Assignee: Shanghai Phaarmaceuticals Holding Co., Ltd.
- Current Assignee: Shanghai Phaarmaceuticals Holding Co., Ltd.
- Current Assignee Address: CN Shanghai
- Agency: Pilloff & Passino LLP
- Agent Sean A. Passino; Rachel K. Pilloff
- Priority: CN201511030013 20151231
- International Application: PCT/CN2016/112942 WO 20161229
- International Announcement: WO2017/114452 WO 20170706
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/4985 ; C07C59/255
Abstract:
Disclosed is a salt of a quinoline derivative, polymorphic forms thereof, preparation methods thereof, a composition, and applications. The SPH1772 ditartrate or crystal form A thereof expresses the following excellent properties: high stability, great bioavailability, excellent pharmacokinetic properties, and better in vivo efficacy than SPH1772 free base.
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