Invention Grant
- Patent Title: T cell receptors
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Application No.: US15006224Application Date: 2016-01-26
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Publication No.: US10344074B2Publication Date: 2019-07-09
- Inventor: Peter Molloy , Nicholas Pumphrey
- Applicant: ADAPTIMMUNE LIMITED
- Applicant Address: GB Abingdon
- Assignee: ADAPTIMMUNE LIMITED
- Current Assignee: ADAPTIMMUNE LIMITED
- Current Assignee Address: GB Abingdon
- Agency: Duane Morris LLP
- Agent Thomas J. Kowalski; Deborah L. Lu
- Priority: GB1313377.2 20130726
- Main IPC: C07K14/725
- IPC: C07K14/725 ; A61K39/00 ; C12N5/0783 ; A61K38/00

Abstract:
The present invention relates to T cell receptors (TCRs) which bind the HLA-A2 restricted FMNKFIYEI (158-166) peptide epitope derived from α Fetoprotein (AFP). Certain preferred TCRs of the invention demonstrate excellent binding characteristics and specificity profiles for this AFP epitope. T cell receptors of the invention may comprise at least one TCR alpha chain variable domain and/or at least one TCR beta chain variable domain, the alpha chain variable domain which may comprise an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1-112 of SEQ ID No: 2, and/or the beta chain variable domain which may comprise an amino acid sequence that has at least 90% identity to the sequence of amino acid residues 1-112 of SEQ ID No: 3.
Public/Granted literature
- US20160137715A1 T CELL RECEPTORS Public/Granted day:2016-05-19
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