Invention Grant
- Patent Title: Anti-IL-1beta antibodies
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Application No.: US15590161Application Date: 2017-05-09
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Publication No.: US10344085B2Publication Date: 2019-07-09
- Inventor: Stefan Dengl , Peter Michael Huelsmann , Christian Gassner , Sebastian Breuer , Olaf Mundigl , Guy Georges , Ralf Schumacher , Guido Hartmann , Sabine Gruener
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffman-La Roche, Inc.
- Current Assignee: Hoffman-La Roche, Inc.
- Current Assignee Address: US NJ Little Falls
- Agent Grant Kalinowski
- Priority: EP14192523 20141110
- Main IPC: C07K16/24
- IPC: C07K16/24 ; C07K16/22 ; A61K39/00
Abstract:
Herein are reported humanized anti-IL-1beta antibodies that are humanized variants of the murine anti-IL-1beta antibody H34. A specific humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 27, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 28.
Public/Granted literature
- US20170247447A1 ANTI-IL-1beta ANTIBODIES AND METHODS OF USE Public/Granted day:2017-08-31
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