Invention Grant
- Patent Title: Directed evolution of a regioselective halogenase for increased thermostability
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Application No.: US15100065Application Date: 2014-11-26
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Publication No.: US10344267B2Publication Date: 2019-07-09
- Inventor: Jared C. Lewis , Catherine Poor , Mary Andorfer , James Payne
- Applicant: The University of Chicago
- Applicant Address: US IL Chicago
- Assignee: The University of Chicago
- Current Assignee: The University of Chicago
- Current Assignee Address: US IL Chicago
- Agency: Norton Rose Fulbright US LLP
- International Application: PCT/US2014/067661 WO 20141126
- International Announcement: WO2015/081228 WO 20150604
- Main IPC: C12N9/04
- IPC: C12N9/04 ; C12N9/02 ; C12P13/22 ; C12P17/10 ; C12P17/18 ; C12P5/00
Abstract:
Compounds and methods are providing involving RebH variants with improved properties. directed evolution based on random mutagenesis was employed to generate a series of RebH variants. RebH variants with improved thermostability and increased activity at elevated temperatures were generated.
Public/Granted literature
- US20170002334A1 DIRECT EVOLUTION OF A REGIOSELECTIVE HALOGENASE FOR INCREASED THERMOSTABILITY Public/Granted day:2017-01-05
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