Invention Grant
- Patent Title: Methods and compositions for treatment of Hunter syndrome
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Application No.: US15279018Application Date: 2016-09-28
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Publication No.: US10344270B2Publication Date: 2019-07-09
- Inventor: Dave Nichols
- Applicant: Shire Human Genetic Therapies, Inc.
- Applicant Address: US MA Lexington
- Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee: Shire Human Genetic Therapies, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Proskauer Rose LLP
- Agent Fangli Chen
- Main IPC: C12N9/16
- IPC: C12N9/16 ; A61K38/46
Abstract:
The present invention provides, among other things, improved methods for purifying I2S protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant I2S protein can be purified from unprocessed biological materials, such as, I2S-containing cell culture medium, using a process involving as few as four chromatography columns.
Public/Granted literature
- US20170073652A1 PURIFICATION OF IDURONATE-2-SULFATASE Public/Granted day:2017-03-16
Information query
