Invention Grant
- Patent Title: Compositions and methods for reduction of allograft recognition and rejection
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Application No.: US15682977Application Date: 2017-08-22
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Publication No.: US10344280B1Publication Date: 2019-07-09
- Inventor: Kayvan Niazi , Shahrooz Rabizadeh , Patrick Soon-Shiong
- Applicant: Nant Holdings IP, LLC
- Applicant Address: US CA Culver City
- Assignee: NANT HOLDINGS IP, LLC
- Current Assignee: NANT HOLDINGS IP, LLC
- Current Assignee Address: US CA Culver City
- Agency: Umberg/Zipser LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N15/113 ; C12N5/0783
Abstract:
Allograft recognition and rejection of donor cells in a host is reduced by limiting or even abrogating expression of the donor cell's MHC-I peptides to avoid CD8+ T-cell recognition and by expression of inhibitory factors to avoid an NK cell mediated cytotoxic response.
Information query
