The present disclosure relates to a production of a high-strength steel sheet with excellent combination of strength and ductility, and a method of manufacturing the same. In accordance with a method of manufacturing a high-strength steel sheet, the method may include: heating a steel sheet which can have a residual austenite upon cooling, to form an austenite; primary cooling the austenitized steel sheet to T1 for a bainite region and subjecting to a primary isothermal transformation; and secondary cooling the primary isothermal transformed steel sheet to T2, which is lower than T1 by 50° C. ore more, for a bainite region, and subjecting to a secondary isothermal transformation.