Invention Grant
- Patent Title: Mammalian cell lines expressing functional nematode acetylcholine receptors and use thereof for high-throughput screening assays
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Application No.: US14849446Application Date: 2015-09-09
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Publication No.: US10345292B2Publication Date: 2019-07-09
- Inventor: Lance Hammerland , Brenda Bondesen , Jean-Marie Chambard , Thierry Vermat , Werner Dittrich , Michel Partiseti , Qing Zhou-Liu , Cathy Cojean , Rachid Boukaiba , Eric Tagat
- Applicant: MERIAL, INC. , Sanofi
- Applicant Address: US GA Duluth FR Paris
- Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH INC.,SANOFI
- Current Assignee: BOEHRINGER INGELHEIM ANIMAL HEALTH INC.,SANOFI
- Current Assignee Address: US GA Duluth FR Paris
- Agent Judy Jarecki-Black; Steffan Finnegan
- Main IPC: C07K14/47
- IPC: C07K14/47 ; G01N33/50 ; C07K14/435 ; G01N33/68 ; C07K14/705 ; C12N5/071
Abstract:
The following discloses mammalian cells lines that stably express functional nematode acetylcholine receptor subunits. The resulting expression of functional ion channels has been made possible by the stable co-expression of the chaperone protein, RIC3. These cell lines are extremely useful for the high throughput screening (HTS) of compounds, to identify new candidate parasiticidal, including nematocidal, active ingredients.
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