In one embodiment, a computer-implemented method for performing deduplication in conjunction with random read and write operations across a namespace that is divided into a plurality of disjoint regions is disclosed. The method includes: maintaining a metadata structure for each of the plurality of disjoint regions via the respective region manager, each metadata structure comprising metadata indicating a physical storage location of one or more data chunks associated with the respective region; and performing a deduplicated write operation. The deduplicated write operation includes: determining whether the disjoint regions comprise a second data chunk identical in content to a first data chunk; and in response to determining one or more of the plurality of disjoint regions other than the first region includes the second data chunk, establishing a reference from the first data chunk to the second data chunk. Corresponding systems and computer program products are also disclosed.