Systems and methods for directly updating the virtual machine memory by interrupt handlers. An example method may comprise: receiving, by a computer system, an interrupt triggered by a physical device; receiving, by an interrupt handling routine, a data frame from the physical device; identifying a virtual machine to receive the interrupt; and responsive to determining that an active memory context on the computer system matches a memory context of the virtual machine, writing, by the interrupt handling routine, the data frame into a memory of the virtual machine.