The disclosed technology is generally directed to peripheral access. In one example of the technology, stored configuration information is read. The stored configuration information is associated with mapping a plurality of independent execution environments to a plurality of peripherals such that the peripherals of the plurality of peripherals have corresponding independent execution environments of the plurality of independent execution environments. A configurable interrupt routing table is programmed based on the configuration information. An interrupt is received from a peripheral. The interrupt is routed to the corresponding independent execution environment based on the configurable interrupt routing table.