For decades, advances in electronics were directly related to the scaling of CMOS transistors according to Moore's law. However, both the CMOS scaling and the classical computer architecture are approaching fundamental and practical limits. A novel memory-centric, reconfigurable, general purpose computing platform is proposed to handle the explosive amount of data in a fast and energy-efficient manner. The proposed computing architecture is based on a single physical resistive memory-centric fabric that can be optimally reconfigured and utilized to perform different computing and data storage tasks in a massively parallel approach. The system can be tailored to achieve maximal energy efficiency based on the data flow by dynamically allocating the basic computing fabric to storage, arithmetic, and analog computing including neuromorphic computing tasks.