The various embodiments herein disclose a system and method for non-invasive computational biopsy analysis. The system is configured to provide diagnosis of human tissue health by non-invasive medical imaging procedures. Further, the system provides a graphical interface providing visual representation of anomalous tissue. The system for computational biopsy includes a Data synthesis module, Signal Filtering module, Classifier module, Analysis Module, Display module, Metric Summary model, Identification of Unknown Tissue module, tissue definition database, and Anomaly Detector module implemented on a computing device.