Multi-sensor signal optimization is facilitated for speech communication. A sensor component including acoustic sensors can be configured to detect sound and generate, based on the sound, first sound information associated with a first sensor of the acoustic sensors and second sound information associated with a second sensor of the acoustic sensors. Further, an audio processing component can be configured to generate filtered sound information based on the first sound information, the second sound information, and a spatial filter associated with the acoustic sensors, determine noise levels for the first sound information, the second sound information, and the filtered sound information, and generate output sound information based on a selection of one of the noise levels or a weighted combination of the noise levels.