One embodiment is directed to a distributed antenna system (DAS) comprising a plurality of nodes, including a head-end unit and a plurality of remote units that are communicatively coupled to the head-end unit. The head-end unit is configured to receive uplink received signals from remote units that wirelessly transceive signals in a coverage area. The head-end unit is configured to sum two or more of the uplink received signals to produce a summed uplink received signal. At least one of the nodes of the DAS includes a processing device configured to determine a transfer function and apply the transfer function to signals in the DAS to cancel, reduce, attenuate, or eliminate intermodulation byproducts in the summed uplink received signal.