An air-cooling heat dissipation device includes a base, a swirling-airflow heatsink, an air pump and a passage connector. The base is located beside an electronic component while the air pump is fixed on the base. The swirling-airflow heatsink is attached on the electronic component and includes a swirling passage defined by a conductive line and a thermal conduction plate collaboratively. An airflow-guiding chamber is defined by the air pump and the base collaboratively, and the airflow-guiding chamber is in communication with the swirling passage by the passage connector. When the air pump is enabled, an ambient air is introduced into the airflow-guiding chamber of the base and transferred to the swirling passage of the swirling-airflow heatsink through a discharge opening of the base and the passage connector. Consequently, a fast swirling air flow is produced to cool the electronic component.