Invention Grant
- Patent Title: Combination products for the treatment of RSV
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Application No.: US16075103Application Date: 2017-02-02
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Publication No.: US10363253B2Publication Date: 2019-07-30
- Inventor: Nina Ysebaert , Nele Isa E. Goeyvaerts , Dirk André E. Roymans , Anil Koul
- Applicant: Janssen Sciences Ireland Unlimited Company
- Applicant Address: IE Ringaskiddy, Co Cork
- Assignee: Janssen Sciences Ireland Unlimited Company
- Current Assignee: Janssen Sciences Ireland Unlimited Company
- Current Assignee Address: IE Ringaskiddy, Co Cork
- Priority: EP16154035 20160203
- International Application: PCT/EP2017/052201 WO 20170202
- International Announcement: WO2017/134133 WO 20170810
- Main IPC: A61K31/496
- IPC: A61K31/496 ; A61K31/7056 ; A61K31/519 ; A61K31/41 ; A61K39/42 ; A61K31/55 ; A61K31/4745 ; A61P31/14 ; A61K31/4184 ; A61K31/437 ; A61K31/52 ; A61K31/53 ; A61K31/5377 ; A61K31/5513 ; A61K31/70 ; C07K16/10 ; A61K39/395 ; A61K39/00

Abstract:
The present invention is directed to the combination of the RSV inhibiting Compound A, i.e. 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl) 1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, and one or more RSV inhibiting Compound B selected from from ribavirin, GS-5806, MDT-637, BTA-9881, BMS-433771, YM-543403, A-60444, TMC-353121, RFI-641, CL-387626, MBX-300, AZ-27, MEDI8897, CR9501, palivizumab, 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1H-benzimidazol-2-yl}methyl)-1 cyclopropyl-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one, 3-[[7-chloro-3-(2 ethyl-sulfonylethyl)imidazo[1,2-a]pyridin-2-yl]methyl]-1-cyclopropyl-imidazo[4,5-c]pyridin-2 one, N-(2-fluoro-6-methylphenyl)-6-(4-(5-methyl-2-(7-oxa-2-azaspiro[3.5]nonan-2 yl)nicotinamido)benzoyl)-5,6-dihydro-4H-benzo[b]thieno[2,3-d]azepine-2-carboxamide, and 4-amino-8-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-6,6-dimethyl-2-(4-methyl 3-nitrophenyl)-3H-imidazo[4,5-h]isoquinoline-7,9(6H,8H)-dione, for treating or ameliorating RSV infection. The invention further relates to the combination product of Compound A and one or more Compound B, a pharmaceutical product comprising Compound A and one or more Compound B, the use of the combination of Compound A and one or more of Compound B—or the pharmaceutical product comprising Compound A and one or more Compound B—for the treatment of RSV infection, and a method of treating or ameliorating RSV infection in a subject in need thereof comprising administering the combination of Compound A and one or more Compound B in an effective amount to said subject.
Public/Granted literature
- US20190054084A1 COMBINATION PRODUCTS FOR THE TREATMENT OF RSV Public/Granted day:2019-02-21
Information query
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