Invention Grant
- Patent Title: Method of manufacturing an osmotic delivery device
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Application No.: US15612581Application Date: 2017-06-02
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Publication No.: US10363287B2Publication Date: 2019-07-30
- Inventor: Thomas R. Alessi , Ryan D. Mercer , Catherine M. Rohloff , Bing Yang
- Applicant: Intarcia Therapeutics, Inc.
- Applicant Address: US MA Boston
- Assignee: INTARCIA THERAPEUTICS, INC.
- Current Assignee: INTARCIA THERAPEUTICS, INC.
- Current Assignee Address: US MA Boston
- Agency: Lathrop Gage LLP
- Agent Brian C. Trinque
- Main IPC: A61K38/26
- IPC: A61K38/26 ; A61K9/00 ; A61K9/10 ; A61K9/16 ; A61K9/70 ; A61K47/14 ; C07K7/06 ; C07K14/605 ; A61K47/12 ; A61K47/20 ; A61K47/26 ; A61K47/32

Abstract:
A suspension formulation of an insulinotropic peptide (e.g., glucagon-like peptide-1 (GLP-1) or exenatide) is described. The suspension formulation comprises (i) a non-aqueous, single-phase vehicle, comprising one or more polymer and one or more one solvent, wherein the vehicle exhibits viscous fluid characteristics, and (ii) a particle formulation comprising the insulinotropic peptide, wherein the peptide is dispersed in the vehicle. The particle formulation further includes a stabilizing component comprising one or more stabilizers, for example, carbohydrates, antioxidants, amino acids, and buffers. Devices for delivering the suspension formulations and methods of use are also described.
Public/Granted literature
- US20170368145A1 OSMOTIC DELIVERY DEVICE COMPRISING AN INSULINOTROPIC PEPTIDE AND USES THEREOF Public/Granted day:2017-12-28
Information query
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