Invention Grant
- Patent Title: Ferroportin inhibitors
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Application No.: US15769148Application Date: 2016-10-21
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Publication No.: US10364239B2Publication Date: 2019-07-30
- Inventor: Franz Dürrenberger , Michael Burgert , Susanna Burckhardt , Wilm Buhr , Aris Kalogerakis , Stefan Reim , Vania Manolova , Susan Boyce , Christopher John Yarnold , Paula Pena , Jon Shepherd , Cristina Lecci , Richard Jarjes-Pike , John Scott
- Applicant: Vifor (International) AG
- Applicant Address: CH St. Gallen
- Assignee: Vifor (International) AG
- Current Assignee: Vifor (International) AG
- Current Assignee Address: CH St. Gallen
- Agency: Rankin, Hill & Clark LLP
- Priority: EP15191176 20151023; EP15191179 20151023
- International Application: PCT/EP2016/075306 WO 20161021
- International Announcement: WO2017/068090 WO 20170427
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/4184 ; A61K31/427 ; A61K31/4355 ; A61K31/437 ; A61K31/4375 ; A61K31/4439 ; A61K31/444 ; A61K31/4985 ; A61K31/501 ; A61K31/506 ; A61K31/5377 ; A61K31/55 ; C07D417/12 ; C07D417/14 ; C07D471/04 ; C07D401/14 ; A61K31/426 ; A61K31/435 ; A61K31/4709 ; A61K31/4725 ; A61K31/497 ; A61K45/06 ; C07D277/56 ; A61P7/06 ; A61P25/28 ; A61P25/16 ; A61P3/12 ; C07D403/14 ; C07D413/04 ; C07D487/04 ; A61K31/16 ; A61K31/4422 ; A61K36/9066

Abstract:
The invention relates to novel compounds of the general formula (A-I), with Het-2 being an optionally substituted bicyclic heteroaryl of the formula (AA) pharmaceutical compositions comprising them and the use thereof as medicaments, in particular for the use as ferroportin inhibitors, more particularly for the use in the prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, such as particularly iron overload states such as in particular thalassemia and hemochromatosis.
Public/Granted literature
- US20180319783A1 Novel Ferroportin Inhibitors Public/Granted day:2018-11-08
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