Invention Grant
- Patent Title: Peptide for inducing regeneration of tissue and use thereof
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Application No.: US14114395Application Date: 2012-04-03
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Publication No.: US10364276B2Publication Date: 2019-07-30
- Inventor: Katsuto Tamai , Takehiko Yamazaki , Tsutomu Kanezaki , Shigeru Sakurai , Yukiko Noguchi , Mayumi Endo , Natsumi Hamabuchi , Kana Naito
- Applicant: Katsuto Tamai , Takehiko Yamazaki , Tsutomu Kanezaki , Shigeru Sakurai , Yukiko Noguchi , Mayumi Endo , Natsumi Hamabuchi , Kana Naito
- Applicant Address: JP Osaka JP Osaka
- Assignee: STEMRIM INC.,OSAKA UNIVERSITY
- Current Assignee: STEMRIM INC.,OSAKA UNIVERSITY
- Current Assignee Address: JP Osaka JP Osaka
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: JP2011-098270 20110426; JP2011-219454 20111003
- International Application: PCT/JP2012/059113 WO 20120403
- International Announcement: WO2012/147470 WO 20121101
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K38/00 ; C07K14/00 ; C07K14/47 ; A61K38/17
Abstract:
(Objective) An objective of the present invention is to provide therapeutic agents that, in association with stimulation of PDGFRα-positive cells such as bone marrow mesenchymal stem cells, promote their mobilization into blood and accumulation in a damaged tissue, and induce tissue regeneration in a living body.(Means for solution) Multiple peptides were synthesized, and the migration-promoting activity of each peptide was evaluated. As a result, the present inventors successfully identified multiple peptides that have migration-promoting activity on a PDGFRα-positive bone marrow mesenchymal stem cell line (MSC-1). Further, the present inventors confirmed that the identified peptides also have migration-promoting activity on skin fibroblasts, which are PDGFRα-positive cells.
Public/Granted literature
- US10160792B2 Peptide for inducing regeneration of tissue and use thereof Public/Granted day:2018-12-25
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