Disclosed are an ABS-based resin composition and a molded article manufactured therefrom. More particularly, the ABS-based resin composition according to the present disclosure includes (a) 22.5 to 50% by weight of a vinyl cyan compound-conjugated diene-based rubber-like polymer-aromatic vinyl compound copolymer resin; (b) 47.5 to 75% by weight of an aromatic vinyl compound-vinyl cyan compound copolymer resin; (c) 1 to 6% by weight of a polyether ester amide resin; and (d) 1.5 to 3% by weight of an ethoxylated alkylamine-based antistatic agent, thereby providing a high humidification amount and less deformation. Accordingly, the present disclosure relates to an ABS-based resin composition suitable for application to disks for air washers, humidifiers, and the like, and a molded article manufactured therefrom.