Invention Grant
- Patent Title: Antisense oligonucleotide directed removal of proteolytic cleavage sites from proteins
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Application No.: US15439776Application Date: 2017-02-22
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Publication No.: US10364432B2Publication Date: 2019-07-30
- Inventor: Wilhelmina M. C. van Roon-Mom , Melvin Maurice Evers , Barry Antonius Pepers , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
- Applicant: Academisch Ziekenhuis Leiden h.o.d.n. LUMC
- Applicant Address: NL Leiden
- Assignee: Academisch Ziekenhuis Leiden h.o.d.n. LUMC
- Current Assignee: Academisch Ziekenhuis Leiden h.o.d.n. LUMC
- Current Assignee Address: NL Leiden
- Agency: TraskBritt
- Priority: EP10172076 20100805
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/11 ; C12N15/113
Abstract:
The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, the method further comprising allowing translation of mRNA produced from the pre-mRNA.
Public/Granted literature
- US20170175117A1 ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS Public/Granted day:2017-06-22
Information query
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