Invention Grant
- Patent Title: Nanoscale imaging of proteins and nucleic acids via expansion microscopy
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Application No.: US15229539Application Date: 2016-08-05
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Publication No.: US10364457B2Publication Date: 2019-07-30
- Inventor: Asmamaw Wassie , Fei Chen , Edward Stuart Boyden , Shahar Alon , George Church , Evan Daugharthy
- Applicant: Massachusetts Institute of Technology , President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Elmore Patent Law Group, P.C.
- Agent Joseph Zucchero; Carolyn Elmore
- Main IPC: C12Q1/6841
- IPC: C12Q1/6841 ; C12Q1/6806 ; G01N1/36
Abstract:
The invention enables in situ genomic and transcriptomic assessment of nucleic acids to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy (ExM) to provide new methods for in situ genomic and transcriptomic assessment of nucleic in a new process referred to herein as “expansion fluorescent in situ hybridization” (ExFISH).
Public/Granted literature
- US20170067096A1 Nanoscale Imaging of Proteins and Nucleic Acids via Expansion Microscopy Public/Granted day:2017-03-09
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