A signal processing circuit with a pressure-sensitive sensor array includes a pressure-sensitive sensor array with M rows and N columns, and an excitation source adapted for outputting positive and negative excitation voltages, wherein: the positive output terminals of the sensing units at a same row of the pressure-sensitive sensor array are connected with each other and act as an output of the row; the negative output terminals of the sensing units at a same column of the pressure-sensitive sensor array are connected with each other and act as an output of the column; so that the whole pressure-sensitive sensor array has a positive excitation input end, a negative excitation input end, M row output signals and N column output signals. The signal processing circuit and method are capable of significantly decreasing an amount of output signal wires of the sensor, reducing connection areas, and improving reliability.