The abnormality diagnosis system of an air-fuel ratio sensor comprising an exhaust purification catalyst, an upstream side air-fuel ratio sensor provided at an upstream side of the exhaust purification catalyst, a downstream air-fuel ratio sensor provided at a downstream side of the exhaust purification catalyst, and a diagnosis device diagnosing the downstream air-fuel ratio sensor for abnormality based on outputs of these air-fuel ratio sensors. The diagnosis device judges that the downstream air-fuel ratio sensor suffers from an abnormality if the output air-fuel ratio of the upstream side air-fuel ratio sensor has become a rich air-fuel ratio richer than a stoichiometric air-fuel ratio, and the output air-fuel ratio of the downstream air-fuel ratio sensor air-fuel ratio has changed from an air-fuel ratio richer than a lean judged reference air-fuel ratio to an air-fuel ratio leaner than the lead judged reference air-fuel ratio. As a result, it is possible to accurately diagnose an abnormality of a downstream air-fuel ratio sensor when using an air-fuel ratio sensor as a downstream side sensor.