A calibration device adapted to be used with a measurement instrument includes a controller, two or more ports, two or more power measurement circuits each connectable with one of the two or more ports, and a non-transitory computer readable storage medium accessible to the controller within which characterization data related to the two or more ports is storable. The calibration device is adapted to be connected with the measurement instrument via a data bus to transmit data and receive commands between the controller and the measurement instrument. The two or more ports are adapted to be interchangeably connectable with ports of the measurement instrument. When the ports of the measurement instrument are connected with the two or more ports of the calibration device and a signal is transmitted by the measurement instrument to the calibration device, a connection configuration between the measurement instrument and the calibration device can be determined based on a detection of power at the two or more power measurement circuits.