Embodiments relate to non-default instruction handling within a transaction. An aspect includes entering a transaction, the transaction comprising a first plurality of instructions and a second plurality of instructions, wherein a default manner of handling of instructions in the transaction is one of atomic and non-atomic. Another aspect includes encountering a non-default specification instruction in the transaction, wherein the non-default specification instruction comprises a single instruction that specifies the second plurality of instructions of the transaction for handling in a non-default manner comprising one of atomic and non-atomic, wherein the non-default manner is different from the default manner. Another aspect includes handling the first plurality of instructions in the default manner. Yet another aspect includes handling the second plurality of instructions in the non-default manner.