The present disclosure relates to a location determination system that includes acoustic transmitting devices, location tags, and a wireless mesh network, where the wireless mesh network uses battery-powered devices. A location tag receives acoustic signals (e.g., ultrasound signals) from an acoustic transmitting device. Clocks from members of the wireless mesh network are synchronized by observation of clock pairings, each clock pair formed by respective clocks in a transmitting device that transmits a message and a receiving device that receives the message. By analyzing the observed clock pairings, a best fit between the clock pairings may be determined. After selecting a reference clock, an acoustic transmission schedule may be propagated to the respective acoustic transmitting device.