Invention Grant
- Patent Title: Biodegradable lipids for the delivery of active agents
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Application No.: US14677801Application Date: 2015-04-02
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Publication No.: US10369226B2Publication Date: 2019-08-06
- Inventor: Martin Maier , Muthusamy Jayaraman , Akin Akinc , Shigeo Matsuda , Pachamuthu Kandasamy , Kallanthottathil G. Rajeev , Muthiah Manoharan
- Applicant: ALNYLAM PHARMACEUTICALS, INC.
- Applicant Address: US MA Cambridge
- Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee Address: US MA Cambridge
- Agency: Blank Rome LLP
- Main IPC: A61K47/18
- IPC: A61K47/18 ; A61K31/13 ; A61K9/127 ; C07D317/30 ; C07C211/09 ; C07C211/10 ; C07C211/11 ; C07C217/08 ; C07C229/12 ; C07C327/22 ; C07C327/28 ; C07C327/32 ; C07C235/06 ; C07C251/38 ; C07F5/02 ; C07D233/54 ; C07D207/32 ; C07D295/08 ; C07D295/12 ; C07D295/14 ; C07C323/12 ; C07C323/58 ; A61K31/7088 ; A61K31/7105 ; A61K9/51 ; A61K31/713
Abstract:
The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
Public/Granted literature
- US20150273068A1 BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS Public/Granted day:2015-10-01
Information query
IPC分类:
