Invention Grant
- Patent Title: Inositol nicotinate crystalline form A and preparation method therefor
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Application No.: US15762849Application Date: 2016-09-21
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Publication No.: US10370334B2Publication Date: 2019-08-06
- Inventor: Liwei Zhu , Xuefeng Mei , Jianrong Wang
- Applicant: WEIFANG SHENGYU PHARMA CO., LTD.
- Applicant Address: CN Weifang, Shandong
- Assignee: WEIFANG SHENGYU PHARMA CO., LTD.
- Current Assignee: WEIFANG SHENGYU PHARMA CO., LTD.
- Current Assignee Address: CN Weifang, Shandong
- Agency: Novick, Kim & Lee, PLLC
- Agent Bin Lu
- Priority: CN201510613142 20150923
- International Application: PCT/CN2016/099643 WO 20160921
- International Announcement: WO2017/050241 WO 20170330
- Main IPC: B01D9/00
- IPC: B01D9/00 ; A61K31/455 ; C07D213/80 ; C07D213/803

Abstract:
Provided are an inositol nicotinate crystalline form A and a preparation method therefor. The X-ray powder diffraction analysis, obtained by using Cu-Kα ray measurement, of the inositol nicotinate crystalline form A has obvious characteristic diffraction peaks at least at 2θ values, expressed in degrees, of 7.05, 7.41, 9.74, 17.80, 19.86, 23.57, 25.48 and 26.20 with an error range of +/−0.2°. The preparation method is one of or a mixed crystallization method of two or more of an evaporation crystallization method, a cooling crystallization method or an anti-solvent crystallization method. The process thereof is simple and easy to operate, and has more selectivity; the inositol nicotinate crystalline form A can be prepared by various methods, and the prepared product has a good crystallization degree and high chemical stability; and the inositol nicotinate crystalline form A prepared by the present method does not have the problem that a residual solvent is out-of-limit.
Public/Granted literature
- US20180273480A1 INOSITOL NICOTINATE CRYSTALLINE FORM A AND PREPARATION METHOD THEREFOR Public/Granted day:2018-09-27
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