Invention Grant
- Patent Title: Aryl acylsulfonamides as BLT1 antagonists
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Application No.: US15768097Application Date: 2016-11-28
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Publication No.: US10370368B2Publication Date: 2019-08-06
- Inventor: Yongxin Han , Satyanarayana Tummanapalli , Phieng Siliphaivanh , Kerrie Spencer
- Applicant: Merck Sharp & Dohme Corp. , Yongxin Han , Satyanarayana Tummanapalli , Phieng Siliphaivanh , Kerrie Spencer
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2016/063807 WO 20161128
- International Announcement: WO2017/095723 WO 20170608
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61P3/10 ; C07D417/14

Abstract:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are antagonists of leukotriene B4 receptor 1 (BLT1) and may be useful in the treatment, prevention and suppression of diseases mediated by the leukotriene B4 receptor 1 (BLT1). The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, insulin resistance, hyperglycemia, dyslipidemia, lipid disorders, obesity, hypertension, Non-alcoholic fatty liver disease/nonalcoholic steatohepatitis, metabolic syndrome, atherosclerosis, and cancer.
Public/Granted literature
- US20180291017A1 ARYL ACYLSULFONAMIDES AS BLT1 ANTAGONISTS Public/Granted day:2018-10-11
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