Invention Grant
- Patent Title: LILRB2 and notch-mediated expansion of hematopoietic precursor cells
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Application No.: US15313043Application Date: 2015-05-21
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Publication No.: US10370643B2Publication Date: 2019-08-06
- Inventor: Irwin D. Bernstein , Chengcheng Zhang , Mi Deng , Zhigang Lu , Junke Zheng
- Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER , BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US WA Seattle US TX Austin
- Assignee: Fred Hutchinson Cancer Research Center,Board of Regents of the University of Texas System
- Current Assignee: Fred Hutchinson Cancer Research Center,Board of Regents of the University of Texas System
- Current Assignee Address: US WA Seattle US TX Austin
- Agency: Lee & Hayes PC
- Agent C. Rachal Winger; Thu Nguyen
- International Application: PCT/US2015/031959 WO 20150521
- International Announcement: WO2015/179633 WO 20151126
- Main IPC: C12N5/071
- IPC: C12N5/071 ; C12N5/074 ; C12N5/078 ; C12N5/0797 ; C07K16/28 ; C12N5/0789 ; C12N5/0775 ; G01N33/569
Abstract:
The current disclosure describes methods of expanding precursor cells for hematopoietic transplantation in subjects. The methods culture precursor cells in media containing an immobilized high molecular weight LILRB2 agonist or an LILRB2 agonist in combination with a Notch agonist. The expanded cells can be used to treat a variety of hematopoietic disorders.
Public/Granted literature
- US20170260508A1 LILRB2 AND NOTCH-MEDIATED EXPANSION OF HEMATOPOIETIC PRECURSOR CELLS Public/Granted day:2017-09-14
Information query
