Invention Grant
- Patent Title: Method for making human pluripotent suspension cultures and cells derived therefrom
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Application No.: US14307100Application Date: 2014-06-17
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Publication No.: US10370644B2Publication Date: 2019-08-06
- Inventor: Benjamin Fryer , Daina Laniauskas , Marcia Blackmoore , Haiyun Wang , Kostadinka Lilova , Shelley Nelson , Elizabeth Rosocha
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agency: Klarquist Sparkman, LLP
- Main IPC: C12N5/074
- IPC: C12N5/074 ; C12N5/071
Abstract:
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering. The methods involve preparing the aggregated cell clusters followed by differentiation of these clusters.
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