Invention Grant
- Patent Title: Target antigen discovery, phenotypic screens and use thereof for identification of target cell specific target epitopes
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Application No.: US14897892Application Date: 2014-06-20
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Publication No.: US10370651B2Publication Date: 2019-08-06
- Inventor: Yan Chen , Steven M. Shamah
- Applicant: X-BODY, INC.
- Applicant Address: US MA Waltham
- Assignee: X-BODY, INC.
- Current Assignee: X-BODY, INC.
- Current Assignee Address: US MA Waltham
- Agency: Lathrop Gage LLP
- Agent James H. Velema, Esq.
- International Application: PCT/US2014/043454 WO 20140620
- International Announcement: WO2014/209801 WO 20141231
- Main IPC: C40B30/04
- IPC: C40B30/04 ; C12N15/10 ; G01N33/68
Abstract:
The invention provides methods and compositions for identifying binding polypeptides (e.g., antibodies or antigen binding fragments thereof) that specifically binds to a cell-surface antigen. The methods of the invention generally comprise contacting a variegated nucleic acid-display library of binding polypeptides with a cell-surface antigen displayed on the exterior surface of a cell; and isolating from the library at least one library member that specifically binds to the cell-surface antigen on the exterior surface of the cell.
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