Invention Grant
- Patent Title: Double-stranded ribonucleic acid for adjuvants
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Application No.: US15791742Application Date: 2017-10-24
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Publication No.: US10370670B2Publication Date: 2019-08-06
- Inventor: Tetsuo Nakano , Eitora Yamamura
- Applicant: KYOWA HAKKO BIO CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: KYOWA HAKKO BIO CO., LTD.
- Current Assignee: KYOWA HAKKO BIO CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Leydig, Voit & Mayer, Ltr.
- Priority: JP2012-267012 20121206; JP2013-145471 20130711
- Main IPC: A61K39/39
- IPC: A61K39/39 ; C12N15/117 ; C12N15/11 ; A61K31/713

Abstract:
The invention provides a double-stranded ribonucleic acid (dsRNA) having a chain length suitable for simultaneously showing low toxicity and high function in the use of an adjuvant and the like, and resisting variation of chain length even when subjected to a heating and cooling treatment, or a salt thereof; an immune potentiator, adjuvant, pharmaceutical product and the like containing the dsRNA and the like; and a production method of such dsRNA and the like. The invention is characterized in that the weight average chain length of two or more single-stranded ribonucleic acids (ssRNAs) constituting the first chain constituting dsRNA is not more than ½ of the weight average chain length of one ssRNA constituting the second chain.
Public/Granted literature
- US20180044678A1 DOUBLE-STRANDED RIBONUCLEIC ACID FOR ADJUVANTS Public/Granted day:2018-02-15
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