A chromatography device includes a unitary body that mounts and connects together as an integrated unit a chromatography column, an sample injector and a detector cell. The device components are arranged generally along X-Y-Z space axes. This arrangement allows hydraulic connection of all the components without additional tubing, fittings, or threaded ports. It also allows an integrated chromatography device to be produced inexpensively by machining or injection molding. The disclosed arrangement allows a user to have convenient access to the components for replacement or service. In addition, the disclosed construction enhances chromatography efficiency, reduces pressure, improves temperature control, and eliminates cross-contamination.