Described herein are methods, systems, and software for accommodating failover of a content node in a content delivery network. In one example, a method of operating a content node includes receiving a communication for an end user device from a control node, wherein an interrupted content node previously handled the communication. The method further includes determining if the communication includes a synchronization packet and identifying connection information for the communication. The method also provides, if the communication includes a synchronization packet, accepting the communication and handling delivery for the end user device. The method also includes, if the communication does not include the synchronization packet, determining if a match exists between the connection information for the communication and connection information stored in a flow table, and handling the communication based on the match.