A method for computer-aided diagnosis of skin lesions includes obtaining a dermoscopic image, convolving the dermoscopic image in a plurality of convolutional layers, obtaining deconvolved outputs of at least two convolutional layers of the plurality of convolutional layers, obtaining side-output feature maps by applying loss functions to the deconvolved outputs of the at least two convolutional layers, obtaining a first concatenated feature map by concatenating the side-output feature maps with different first weights, obtaining a second concatenated feature map by concatenating the side-output feature maps with different second weights, and producing a final score map by convolving the first and second concatenated feature maps in a final convolutional layer followed by a loss layer. Also disclosed: a computer-readable medium embodying instructions for the method, and an apparatus configured to implement the method.